Brain Anatomic Magnetic Resonance Imaging in Childhood Bipolar Disorder
McLean Hospital
Jean A. Frazier, M.D.
Bipolar disorder has been researched in the past; however, there is still much more to be investigated. There has been very little research regarding co-occurrence of bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD) in children. The purpose of this study is to assess any structural abnormalities in the brain that may be contributing to children having bipolar disorder and ADHD. In doing so, we hope to gain a better understanding of the coexistence of BPD and ADHD in children. We will be conducting interviews, cognitive/ neuropsychological testing, a physical/ neurological examination, and magnetic resonance imaging (MRI) with subjects between 4 and 19 years of age who meet DSM-IV criteria for bipolar disorder, ADHD, or bipolar disorder and ADHD. We will be conducting these same measures with controls that have no DSM-IV diagnoses and no family history of ADHD, bipolar disorder, or psychotic disorders.
Keywords: ADHD, Bipolar disorder, MRI, brain
Grant Support: NIMH K08 MH01573- "Brain Anatomic Magnetic Resonance Imaging in Childhood Bipolar Disorder"
Project Sites: McLean Hospital
Project Director: Jean Frazier, M.D., 115 Mill Street, Belmont, MA 02478
Representative Publications:
Jacobsen LK, Giedd JN, Rajapakse JC, Hamburger SD, Vaituzis C, Frazier JA, Lenane MC, Rapoport JL. Quantitative Magnetic Resonance Imaging of the Corpus Callosum in Childhood Onset Schizophrenia. Psychiatry Research: Neuroimaging Section 1997; 68: 77-86.
Wilens T, Biederman J, Spencer T, Frazier J, Prince J, Bostic J, Rater M, Soriano J, Hatch M, Sienna M, Millstein R, Abrantes A. A controlled trial of high dose pemoline for adults with ADHD. Journal of Clinical Psychopharmacology 1999;19: 257-264.
Frazier JA, Meyer MC, Biederman J, Wozniak J, Wilens T, Spencer T, Kim G, Shapiro S. Risperidone Treatment for Juvenile Bipolar Disorder: A Retrospective Chart Review. Journal of the American Academy of Child and Adolescent Psychiatry; 1999; 38: 960-965.
Frazier J.A, Biederman J., Tohen M. Feldman P. D., Jacobs, T. G., Toma V., Rater M.A., Tarazi R. A., Kim G. S., Garfield S. B., Sohma M., Gonzalez-Heydrich J. Risser R. C. Nowlin Z. M. A Prospective Open-Label Treatment Trial of Olanzapine Monotherapy in Children and Adolescents with Bipolar Disorder. Journal of Child and Adolescent Psychopharmacology. 2001; 11 (3): 239 - 250
Frazier J.A., Doyle R., Chiu S., Coyle J. Clinical Case Report: Can a Child with Asperger's Syndrome have Comorbid Bipolar Disorder? Invited Clinical Case Conference. American Journal of Psychiatry. In Press.