Harvard Department Of PsychiatryHarvard Medical School

NEUROPSYCHOLOGY OF AGE RELATED DISEASES

Geriatric Neuropsychology Laboratory, Geriatric Research, Education, and Clinical Center VA Boston Healthcare: Jamaica Plain Campus

William P. Milberg, Ph.D., and Regina McGlinchey-Berroth, Ph.D. Christopher Brady, Ph.D

The Geriatric Neuropsychology Laboratory conducts a variety of projects concerned with the disruption of higher cognitive functions by diseases that primarily affect older adults. The laboratory has recently focused on identifying early cognitive changes in executive function abilities in patients at risk for cerebrovascular disease. Current projects include studies of healthy older veterans, community dwelling African-American adults in conjunction with the Harvard Claude D. Pepper Older American Independence Center , and the Nurses Health Study in collaboration with the Massachusetts Epidemiology and Information Center (MAVERIC). The laboratory also maintains several projects in basic cognitive neuroscience. Current projects in this area include experiments concerned with the neuromodulation of semantic memory deficits in patients with Alzheimer's Disease; an analysis of preserved and impaired visual information processing in stroke patients with hemispatial neglect; the development of neural network models of aphasic language disorders; an analysis of Eye Blink Conditioning in patients with Alcoholic Korsakoff's Syndrome; and Alcoholism. In addition, the laboratory is devoted to the translation of basic research in cognitive neuroscience into clinically useful instruments and assessment techniques.

Key Words. Cerebrovascular Disease, Executive Functions, Dementia, Hemispatial Neglect, Neuropsychology, Semantic memory.

Grant Support. NIH: NS29342-01A3, Cognitive Processing in Hemispatial Neglect (WPM, RMB, MV). Veteran's Administration Merit Review: 097-44-3765/001, Cognitive Deficits in Language Function in Alzheimer's Disease (WPM, RMB). NIH: NS26985-06

Project Sites. Geriatric Research Education and Clinical Center (GRECC), West Roxbury VAMC; Dept. of Neurology, Healthsouth Braintree Rehabilitation Behavioral Neurology Unit, Beth Israel Hospital, Hebrew Rehabilitation Home for the Aged;

Project Director.William P. Milberg, Ph.D., GRECC (182JP), VA Boston Healthcare-JP, 150 South Huntington Avenue, Boston, MA 02459.

Contact Person. William P. Milberg, Ph.D. Tel. No. (617) 232-9500 x2946. FAX. (617)278-4544. EMAIL. wpm@bu.edu

Training Opportunities. Currently there are two pre-doctoral interns and one geropsychology post-doctoral fellow. There is usually one NIH funded Research Fellow but this position is currently vacant, three-four research associates. Supervision of medical fellows and graduate students is also available.

Representative Publications.

Milberg ,W.P., & Blumstein, S.E. (2000). Back to the future: Reclaiming aphasia from cognitive neuroscience. Brain and Language, 71(11), 160-163.

Milberg, W.P., McGlinchey-Berroth, R., Duncan, K.M., & Higgins, J. (1999). Alterations in the dynamics of semantic activation in Alzheimer's disease: Evidence for the Gain/Decay hypothesis of a disorder of semantic memory. Journal of the International Neuropsychological Society, 5(7), 641-658.

McGlinchey-Berroth, R., Brawn, C.M. & Disterhoft, J.F. Temporal discrimination learning in severe amnesics reveals a deficit in the timing of eyeblink conditioned responses. Behavioral Neuroscience. 1999; 113: 1-9

Esterman, M., McGlinchey-Berroth, R., & Milberg, W. (2000). Parallel and Serial Search in hemispatial neglect: Evidence for preserved preattentive but impaired attentive processing. Neuropsychology, 14, 599-611.

Brady, CB, Spiro A, McGlinchey-Berroth, R, Milberg, W. (2001) Stroke Risk is Associated with Executive Function Decline J. Gerontology (In Press)

Department Of Psychiatry Harvard Medical School - 2 West - Room 305 - 401 Park Drive - Boston, MA 02215