Stanley Foundation Bipolar Disorders Research Center
McLean Hospital
Bruce M. Cohen, M.D., Ph.D., William Carlezon, Jr., Ph.D., Perry F. Renshaw, M.D., Ph.D., Andrew L. Stoll, M.D., Deborah A. Yurgelun-Todd, Ph.D.
The Stanley Foundation Bipolar Disorders Research Center is a consortium of investigators spanning clinical, laboratory, and brain imaging disciplines working together to discover new and more effective treatments for bipolar and related disorders. The Center has the resources to design, develop, and test novel potential therapeutic agents, and is working on approaches, such as altering the characteristics of nerve cell membranes or energy metabolism, that are different than those commonly pursued at pharmaceutical companies or in other university settings. These approaches may offer therapeutic benefits unavailable with current treatments. There are opportunities to work in brain imaging, laboratory or clinical trials components of this research.
Key words: Bipolar Disorder, Treatment Development, Clinical Trials, Brain Imaging, Behavioral Pharmacology
Grant Support: Stanley Foundation and individual investigator federal, foundation and industry support.
Project Site: McLean Hospital
Project Director: Bruce M. Cohen, M.D., Ph.D., McLean Hospital, 115 Mill Street, Belmont, MA 02478
Contact Person: Bruce M. Cohen, M.D., Ph.D., phone: (617) 855-3227; fax: (617) 855-3670; email: cohenb@mclean.harvard.edu
Training Opportunities: This is a program site for departmental trainees
Representative Publications:
Carlezon WA Jr., Pliakas AM, Parow Am, Cohen BM, Renshaw PF. Behavioral effects of the citicoline (CDP-choline) metabolite cytidine in rats. Biological Psychiatry. Accepted for publication, 2002.
Loeber RT, Gruber SA, Cohen BM, Renshaw PF, Sherwood AR, Yurgelun-Todd DA. Cerebellar blood volume in bipolar patients correlates with medication. Biological Psychiatry. 2002;51:370-376.
Stoll AL, Locke CA. Omega-3 fatty acids in mood disorders: A review of neurobiologic and clinical actions. In: Natural Medications for Psychiatric Disorders (D. Mischoulon and J. Rosenbaum, eds.), Lippincott, 2002.