is The Gregor Mendel Professor of Genetics and Professor of Medicine at Harvard Medical School and Senior Geneticist at Brigham and Women’s Hospital. He is also an Investigator of the Howard Hughes Medical Institute, and is a Pew Scholar in the biomedical sciences. He is a recipient of the G.H.A. Clowes Memorial Award, the Paul Marks Prize in cancer research, the Michael E. DeBakey Award for research excellence, and the 2002 National Academy of Sciences Award in molecular biology. Dr. Elledge was elected to the National Academy of Sciences in 2003.

The Elledge lab uses model organisms to characterize cell cycle control and the cellular response to DNA damage. They have identified and characterized a signal transduction pathway that senses and responds to DNA damage. The lab is interested in technology development to aid in gene and drug discovery, and most recently applied a screen to identify transcriptional regulators of telomerase, an important player in human cancer. Currently they are initiating genome wide siRNA screens for regulators in cell cycle, checkpoint signaling tumorigenesis and cell proliferation. Until recently large-scale genetic screens have not been possible in mammals. The Elledge Lab initiated a genetic screen to find transcriptional regulators of human telomerase, an important player in human cancer. Using a technique that places endogenous genes under the control of a regulated promoter, we uncovered multiple negative regulators of this pathway.