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Drosophila wing disc (Image by
Dr. Jairaj K. Acharya) |
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| Publications |
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| Peer-reviewed Articles |
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| Anderson, R., Bitterman, K., Wood, J., Medvedik,
O. and Sinclair, DA. Nicotinamide and Pnc1 govern lifespan extension
by calorie restriction in S. cerevisiae. Nature, 2003; 423:181-185 |
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| Howitz, KT., Bitterman, KJ., Cohen, HY., Lamming, DW., Lavu, S., Wood, JG., Zipkin, RE., Chung P., Kisielewski, A., Zhang, L., Scherer, B., Sinclair DA. Small molecule sirtuin activators that extend S.
cerevisiae lifespan. Nature 2003; 425:191-196. |
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| Anderson, RA., Latorre-Esteves, M., Neves, A., Lavu, S., Taylor, C., Howitz, KT., Santos, H., Sinclair, DA. Lifespan extension by calorie restriction is independent of NAD fluctuation. Science 2003; 302:2124-2126. |
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| Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase. Science 2004 303, 2011-5. |
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| Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the ageing human brain. Nature. 2004 429(6994):883-9 |
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| Cohen, HY, Lavu, S., Bitterman, KJ, Hekking, B., Imahiyerobo, TA, Miller, C., Frye, R., Ploegh, H, Kessler, BM, Sinclair DA. Acetylation of the C-terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Molecular
Cell, 13: 627-38 |
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| Cohen, H.Y., Miller, C., Bitterman, K.J., Wall, N.R., Hekking, B., Kessler, B., Howitz, KT., Gorospe, M., de Cabo, R. and Sinclair, DA. Calorie restriction promotes cell survival by inducing SIRT1. Science, 2004.; 305(5682):390-2 |
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| Wood, J., Rogina, B., Lavu, S., Howitz, K.T., Helfand, S.L., Tatar, M., Sinclair, DA. Sirtuin activators mimic calorie restriction and delay aging in metazoans. Nature, 2004; 430:686-9 |
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| A gamma-secretase-independent mechanism of signal transduction by the amyloid precursor protein.J
Biol Chem. 2005 Nov 4;280(44):36895-90 |
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| Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum
Mol Genet. 2005 May 1;14(9):1231-4 |
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| Lamming, D, Latorre-Esteves, M, Medvedik, O, Wong, S.N., Tsang, F.A, Wang, C, Lin, S-J, Sinclair, DA. HST2 mediates SIR2-independent lifespan extension by calorie restriction. Science, 2005; 309(5742):1861-4. |
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Reviews and Chapters. |
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| Lamming, D. Wood, J., Sinclair, DA. Small Molecule Mimetics of Calorie Restriction: evidence for xenohormesis. Molecular Microbiology Reviews, 2004; 53(4):1003-9 |
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| Howitz, K.T. and Sinclair, DA. Dietary restriction
and small molecule mimetics In Handbook of Aging, Austad, S. and
Masoro, E. eds. 2005, Academic Press. |
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Sinclair, DA. Sirtuins for healthy neurons (2005)
Nature Genetics, 37(4):339-40.
Sinclair, DA. Towards a unified theory
of caloric restriction. (2005) Mech Ageing Dev., 26(9):987-1002. |
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| Howitz, KT. Caloric Restriction, Hormesis and Small
Molecule Mimetic in The Handbook of the Biology of Aging. (2005)
Austad, S and Masoro, E (Eds.) Academic Press. |
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| Sinclair, DA, Guarente, LP. Sirtuins: master regulators
of aging. Scientific American, March issue. |
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