Pamela Silver, Ph.D. is a Professor in the Department of Systems Biology at Harvard Medical School and a member of the Department of Cancer Biology at the Dana Farber Cancer Institute. She studied translocation of proteins across membranes as a graduate student with Bill Wickner at the University of California and nuclear transport as an ACS Postdoctoral Fellow with Mark Ptashne at Harvard University. First as a faculty member at Princeton University, and later at Harvard Medical School, she developed novel genetic and cell biological approaches to study movement of macromolecules in eukaryotic cells. Her current interests range from the systems biology of the nucleus to the use of genomics, chemical genetics, cell-based screening and proteomics in the study of diseases and the brain. She has been the recipient of an NSF Presidential Young Investigator Award, an Established Investigatorship from the American Heart Association, the BBS Mentoring Award from Harvard Medical School and an NIH MERIT award. The Silver group focuses on several major areas in biology from a systems-wide point of view. They model and design biological circuits and parts with well-defined properties for engineering biological systems with an emphasis on intracellular spatial programming. Their recent work has identified new aging regulatory genes in yeast and has led to "cellular oscillator" technology for analyzing cellular aging. The system allows researchers to determine the lifespan of individual yeast cells based on nuclear/cytoplasmic localization.

Direct Contact: Department of Systems Biology Harvard Medical School Warren Alpert Building, Room 425 200 Longwood Avenue Boston, MA 02115 pamela_silver@hms.harvard.edu (617) 432-6401 (phone)

Selected Publications: Carrol, J.S., Liu, X.S., C.R., Brodsky, A.S., Meyer, C.A., Li, W., Szary, A., Shao, W., Hesterman, E., Geistlinger, T.R., Fox, E.A., Silver, P.A., and Brown, M. (2005) Chromosome-wide mapping of estrogen receptor binding reveals long-range combinatorial regulation requiring forkhead proteins. Cell. July 15;122(1):33-43 Casolari, J.M., Brown, C.R., Komili, S., West, J., Hieronymus, H., and Silver, P.A. (2004) Genome-wide localization of the nuclear transport machinery reveals coupling of transcriptional status and nuclear organization. Cell. 117(4):427-39 Hieronymus, H. and Silver, P.A. (2003) Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery. Nat. Genet. 33(2):155-61.