Selected
Publications:
Yu
MC,
Lamming
DW,
Eskin
JA,
Sinclair
DA,
Silver
PA
(2006).
The
role
of
protein
arginine
methylation
in
the
formation
of
silent
chromatin.
Genes
Dev 20(23):3249-54.
Yang H, Baur
JA, Chen A, Miller
C, Sinclair DA
(2006). Design
and synthesis
of compounds
that extend yeast
replicative lifespan.
Aging
Cell PMID:
17156081
North BJ, Sinclair
DA (2006). Sirtuins:
a conserved key
unlocking AceCS
activity. Trends
Biochem Sci 32(1):1-4.
Baur JA, Pearson
KJ, Price NL,
Jamieson HA,
Lerin C, Kalra
A, Prabhu VV,
Allard JS, Lopez-Lluch
G, Lewis K, Pistell
PJ, Poosala S,
Becker KG, Boss
O, Gwinn D, Wang
M, Ramaswamy
S, Fishbein KW,
Spencer RG, Lakatta
EG, Le Couteur
D, Shaw RJ, Navas
P, Puigserver
P, Ingram DK,
de Cabo R, Sinclair
DA (2006). Resveratrol
improves health
and survival
of mice on a
high-calorie
diet. Nature 444(7117):337-42.
Yang H, Lavu
S, Sinclair DA.
Nampt/PBEF/Visfatin:
a regulator of
mammalian health
and longevity?
Exp Gerontol 41(8):718-26.
Baur JA, Sinclair
DA. Therapeutic
potential of
resveratrol:
the in vivo evidence.
Nat Rev
Drug Discov 5(6):493-506.
Mai A, Massa
S, Lavu S, Pezzi
R, Simeoni S,
Ragno R, Mariotti
FR, Chiani F,
Camilloni G,
Sinclair DA.
Design, synthesis,
and biological
evaluation of
sirtinol analogues
as class III
histone/protein
deacetylase (Sirtuin)
inhibitors. J
Med Chem 48(24):7789-95. Lin, S-J, Sinclair,
DA (2005) HST2 mediates SIR2-independent
lifespan extension
by calorie restriction. Science,
July 28 epub SciExpress.
Wood, J, Rogina,
B, Lavu, S, Howitz,
KT, Helfand,
SL, Tatar, M,
Sinclair, DA.
(2004). Sirtuin
activators mimic
calorie restriction
and delay aging
in metazoans. Nature,
430(7000):686-9.
Cohen, HY, Miller,
C, Bitterman,
KJ, Wall, NR,
Hekking, B, Kessler,
B, Howitz, KT,
Gorospe, M, de
Cabo, R Sinclair,
DA. (2004) Calorie
restriction promotes
cell survival
by inducing SIRT1. Science,
305(5682):390-2
Howitz,
KT., Bitterman,
KJ., Cohen, HY.,
Lamming, DW., Lavu,
S., Wood, JG.,
Zipkin, RE., Chung
P., Kisielewski,
A., Zhang, L.,
Scherer, B., Sinclair
DA. (2003) Small
molecule sirtuin
activators that
extend S. cerevisiae
lifespan. Nature,
425:191-196
|
David
Sinclair, Ph.D. -
is Co-Director
of the Paul F.
Glenn
Laboratories for
the Molecular Biology
of Aging, an Associate
Professor of Pathology
at Harvard Medical
School, Associate
Member of the Broad
Institute for Systems
Biology, and co-founder
of Sirtris Pharmaceuticals,
Waltham, MA. Dr.
Sinclair's research
aims to identify
conserved longevity
control pathways
and devise small
molecules that
activate them,
with a view to
preventing and
treating diseases
caused by aging.
His lab was the
first to identify
small molecules
called STACs that
can activate the
SIRT pathway and
extend lifespan
of a diverse species.
They also discovered
key components
of the aging regulatory
pathway in yeast
and is now focused
on finding genes
and STACs that
extend the healthy
lifespan of mice.
Marcia
Haigis, Ph.D. -
Assistant Professor
of Pathology at Harvard
Medical School. Dr.
Haigis's lab is focused
on understanding the
role that mitochondria
play in mammalian aging
and disease. Mitochondria
are dynamic organelles
that provide cells
with energy even during
dramatic changes in
diet, stress and development.
Mitochondria are also
a major site for reactive
oxygen species production,
ion homeostasis, and
apoptosis. Not surprisingly,
mitochondrial dysfunction
has been implicated
in aging, neurodegeneration
and metabolic diseases,
such as diabetes.