 David
Sinclair, Ph.D. - is Director of
the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, an Associate Professor
of Pathology at Harvard Medical School,
Associate Member of the Broad Institute
for Systems Biology, and co-founder of Sirtris
Pharmaceuticals, Waltham, MA. Dr. Sinclair's
research aims to identify conserved longevity
control pathways and devise small molecules
that activate them, with a view to preventing
and treating diseases caused by aging. His
lab was the first to identify small molecules
called STACs that can activate the SIRT
pathway and extend lifespan of a diverse
species. They also discovered key components
of the aging regulatory pathway in yeast
and is now focused on finding genes and
STACs that extend the healthy lifespan of
mice.
Dr. Sinclair obtained a BS with first-class
honors at the University of New South Wales,
Sydney, and received the Commonwealth Prize
for his research. In 1995, he receive d
a Ph.D. in Molecular Genetics and was awarded
the Thompson Prize for best thesis work.
He worked as a postdoctoral researcher with
Dr. Leonard Guarente at M.I.T. being recruited
to Harvard Medical School at the age of
29. Dr. Sinclair has received several additional
awards including a Helen Hay Whitney Postdoctoral
Award, and a Special Fellowship from the
Leukemia Society, a Ludwig Scholarship,
a Harvard-Armenise Fellowship, an American
Association for Aging Research Fellowship,
and is currently a New Scholar of the Ellison
Medical Foundation. He recently won the
Genzyme Outstanding Achievement in Biomedical
Science Award for 2004.
Selected Publications:
Howitz, KT., Bitterman, KJ.,
Cohen, HY., Lamming, DW., Lavu, S.,
Wood, JG., Zipkin, RE., Chung P.,
Kisielewski, A., Zhang, L., Scherer,
B., Sinclair DA. (2003) Small molecule
sirtuin activators that extend S.
cerevisiae lifespan. Nature,
425:191-196
Cohen, HY, Miller, C, Bitterman, KJ,
Wall, NR, Hekking, B, Kessler, B,
Howitz, KT, Gorospe, M, de Cabo, R
Sinclair, DA. (2004) Calorie restriction
promotes cell survival by inducing
SIRT1. Science,
305(5682):390-2
Wood, J, Rogina, B, Lavu, S, Howitz,
KT, Helfand, SL, Tatar, M, Sinclair,
DA. (2004). Sirtuin activators mimic
calorie restriction and delay aging
in metazoans. Nature,
430(7000):686-9.
Lin, S-J, Sinclair, DA (2005) HST2
mediates SIR2-independent
lifespan extension by calorie restriction.
Science,
July 28 epub SciExpress. |
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